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For patients who have plateaued on maximum-dose semaglutide, switching to tirzepatide is the most evidence-backed next step

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They work by slowing stomach emptying, curbing food noise and cravings, and improving metabolic response, but they also introduce a unique routine of weekly shots, fluctuating medication levels and side effects that ebb and flow over the course of the week

The transition between the two medications requires careful dose matching to avoid gaps in coverage or accidental overdosing

doi: 10.1371/journal.pone.0174099 59 KarlssonF

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